Designing Instruction with Generative AI offers a novel set of tools and strategies for leveraging generative AI to create engaging and personalized learning experiences. While instructional designers are a tremendous asset to higher education, not all colleges or universities have the robust staff needed to support all instructors on staff or large student populations. Drawing on a wealth of research, professional experience, and strategic insights, this book equips new and seasoned teaching faculty and trainers with step-by-step directions on how freely accessible artificial intelligence software can assist with all aspects of the course creation and instruction process and cater to the needs of diverse learners. Each chapter offers forward-thinking and empirically validated ways to help faculty create and improve instructional materials, course design, and learning environments while supporting their digital literacies. Rather than introduce AI as a means of outsourcing subject-area expertise, critical thinking, or cognitive processes, the author instead emphasizes its potential to build on traditionally honed knowledge and foundational instructional design practices. From optimizing course alignment and accessibility practices to fostering active learning, motivation, and engagement, educators will find new solutions to common teaching and learning challenges with greater efficiency in time and capacity.